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Figure 1. Example applications of single molecule force spectroscopy techniques in dissecting membrane receptors dynamics. A Magnetic tweezers dissecting the conformation changes under stretching forces (Wu et al. 2019). B–D Multiplexed SMFS techniques investigating the dynamic functions of in-situ TCR/pMHC interactions with fluorescent spectroscopy combined with BFP (B) (Liu et al. 2014), AFM (C) (Hu and Butte 2016) and OT (D) (Feng et al. 2017)
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Figure 2. Schematics for antibody-based immunotherapies potentially sustaining biomechanical regulations. A PD-1 monoclonal antibody captured by FcγRs on macrophage blocks PD-1 on T cell. B CD3/CD19 bispecific antibody physically connect T cell with tumor cells expressing CD19. C CD19 CAR-T cell engages CD19 molecules on tumor cell
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Figure 3. Perspective for multiplexed single molecule force spectroscopy incorporating patch clamp and fluorescent imaging techniques
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