| Bers DM (2002) Cardiac excitation-contraction coupling. Nature 415(6868): 198−205 doi: 10.1038/415198a |
| Bootman MD, Smyrnias I, Thul R, Coombes S, Roderick HL (2011) Atrial cardiomyocyte calcium signalling. Biochim Biophys Acta 1813(5): 922−934 doi: 10.1016/j.bbamcr.2011.01.030 |
| Bray MA, Geisse NA, Parker KK (2007) Multidimensional detection and analysis of Ca2+ sparks in cardiac myocytes. Biophys J 92(12): 4433−4443 doi: 10.1529/biophysj.106.089359 |
| Brochet DX, Xie W, Yang D, Cheng H, Lederer WJ (2011) Quarky calcium release in the heart. Circ Res 108(2): 210−218 doi: 10.1161/CIRCRESAHA.110.231258 |
| Brochet DX, Yang D, Cheng H, Lederer WJ (2012) Elementary calcium release events from the sarcoplasmic reticulum in the heart. Adv Exp Med Biol 740: 499−509 |
| Cheng H, Lederer WJ (2008) Calcium sparks. Physiol Rev 88(4): 1491−1545 doi: 10.1152/physrev.00030.2007 |
| Dridi H, Kushnir A, Zalk R, Yuan Q, Melville Z, Marks AR (2020) Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target. Nat Rev Cardiol 17(11): 732−747 doi: 10.1038/s41569-020-0394-8 |
| Houser SR (2023) Proarrhythmic remodeling of atrial myocyte Ca2+ handling in atrial fibrillation. JaccBasic Transl Sci 8(1): 16−18 |
| Huang YF, Lei CX, Xie WJ, Yan L, Wang YR, Yuan S, Wang J, Zhao Y, Wang ZJ, Yang XY, Qin XH, Fang Q, Fang LG, Guo XX (2021) Oxidation of ryanodine receptors promotes Ca2+ leakage and contributes to right ventricular dysfunction in pulmonary hypertension. Hypertension 77(1): 59−71 doi: 10.1161/HYPERTENSIONAHA.120.15561 |
| Liu T, Xiong F, Qi XY, Xiao JN, Villeneuve L, Abu-Taha I, Dobrev D, Huang CX, Nattel S (2020) Altered calcium handling produces reentry-promoting action potential alternans in atrial fibrillation-remodeled hearts. Jci Insight 5(8): e133754. https://doi.org/10.1172/jci.insight.133754 doi: 10.1172/jci.insight.133754 |
| Lu FJ, Ma Q, Xie WJ, Liou CL, Zhang DH, Sweat ME, Jardin BD, Naya FJ, Guo YX, Cheng HP, Pu WT (2022) CMYA5 establishes cardiac dyad architecture and positioning. Nat Commun 13(1): 2185. https://doi.org/10.1038/s41467-022-29902-4 doi: 10.1038/s41467-022-29902-4 |
| Lu FJ, Zhao Y, Xie WJ, Guo QJ, Wang SQ, Wang XH, Cheng HP (2020) Imaging sarcoplasmic reticulum Ca2+ signaling in intact cardiac myocytes. Circulation 142(15): 1503−1505 doi: 10.1161/CIRCULATIONAHA.120.047784 |
| Marks AR (2023) Targeting ryanodine receptors to treat human diseases. J Clin Invest 133(2): e162891. https://doi.org/10.1172/JCI162891 doi: 10.1172/JCI162891 |
| Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR (2022) Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment. Sci Adv 8(29): eabo1272. https://doi.org/10.1126/sciadv.abo1272 doi: 10.1126/sciadv.abo1272 |
| Mohamed BA, Hartmann N, Tirilomis P, Sekeres K, Li W, Neef S, Richter C, Zeisberg EM, Kattner L, Didie M, Guan K, Schmitto JD, Lehnart SE, Luther S, Voigt N, Seidler T, Sossalla S, Hasenfuss G, Toischer K (2018) Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression. Sci Transl Med 10(458): eaan0724. https://doi.org/10.1126/scitranslmed.aan0724 doi: 10.1126/scitranslmed.aan0724 |
| Nattel S, Burstein B, Dobrev D (2008) Atrial remodeling and atrial fibrillation mechanisms and implications. Circ Arrhythm Electrophysiol 1(1): 62−73 doi: 10.1161/CIRCEP.107.754564 |
| Shan J, Xie W, Betzenhauser M, Reiken S, Chen BX, Wronska A, Marks AR (2012) Calcium leak through ryanodine receptors leads to atrial fibrillation in 3 mouse models of catecholaminergic polymorphic ventricular tachycardia. Circ Res 111(6): 708−717 doi: 10.1161/CIRCRESAHA.112.273342 |
| Shoemaker MB, Yoneda ZT, Crawford DM, Akers WS, Richardson T, Montgomery JA, Phillips S, Shyr Y, Saavedra P, Estrada JC, Kanagasundram A, Shen ST, Michaud GF, Crossley G, Ellis CR, Knollmann BC (2022) A mechanistic clinical trial using (R)- versus (S)-propafenone to test RyR2 (ryanodine receptor) inhibition for the prevention of atrial fibrillation induction. Circ Arrhythm Electrophysiol 15(10): e010713. https://doi.org/10.1161/CIRCEP.121.010713 doi: 10.1161/CIRCEP.121.010713 |
| Steinberg C, Roston TM, van der Werf C, Sanatani S, Chen SRW, Wilde AAM, Krahn AD (2023) RYR2-ryanodinopathies: from calcium overload to calcium deficiency. Europace 25(6): euad156. https://doi.org/10.1093/europace/euad156 doi: 10.1093/europace/euad156 |
| Szedlak P, Steele DS, Hopkins PM (2023) Cardiac muscle physiology. BJA Educ 23(9): 350−357 doi: 10.1016/j.bjae.2023.05.004 |
| Tarifa C, Vallmitjana A, Jimenez-Sabado V, Marchena M, Llach A, Herraiz-Martinez A, Godoy-Marin H, Nolla-Colomer C, Ginel A, Vinolas X, Montiel J, Ciruela F, Echebarria B, Benítez R, Cinca J, Hove-Madsen L (2023) Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes. Jacc Basic Transl Sci 8(1): 1−15 doi: 10.1016/j.jacbts.2022.07.013 |
| Tomek J, Nieves-Cintron M, Navedo MF, Ko CY, Bers DM (2023) SparkMaster 2: a new software for automatic analysis of calcium spark data. Circ Res 133(6): 450−462 doi: 10.1161/CIRCRESAHA.123.322847 |
| von Wegner F, Both M, Fink RHA (2006) Automated detection of elementary calcium release events using the A Trous wavelet transform. Biophys J 90(6): 2151−2163 doi: 10.1529/biophysj.105.069930 |
| Walden AP, Dibb KM, Trafford AW (2009) Differences in intracellular calcium homeostasis between atrial and ventricular myocytes. J Mol Cell Cardiol 46(4): 463−473 doi: 10.1016/j.yjmcc.2008.11.003 |
| Woo SH, Cleemann L, Morad M (2003) Spatiotemporal characteristics of junctional and nonjunctional focal Ca2+ release in rat atrial myocytes. Circ Res 92(1): e1−11 doi: 10.1161/01.RES.0000052925.89426.09 |
| Xie W, Brochet DX, Wei S, Wang X, Cheng H (2010) Deciphering ryanodine receptor array operation in cardiac myocytes. J Gen Physiol 136(2): 129−133 doi: 10.1085/jgp.201010416 |
| Xie WJ, Santulli G, Guo XX, Gao M, Chen BX, Marks AR (2013) Imaging atrial arrhythmic intracellular calcium in intact heart. J Mol Cell Cardiol 64: 120−123 doi: 10.1016/j.yjmcc.2013.09.003 |
| Xie WJ, Santulli G, Reiken SR, Yuan Q, Osborne BW, Chen BX, Marks AR (2015) Mitochondrial oxidative stress promotes atrial fibrillation. Sci Rep 5: 11427. https://doi.org/10.1038/srep11427 doi: 10.1038/srep11427 |
| Yang S, Li R, Chen J, Li Z, Huang Z, Xie W (2021) Calcium spark detection and event-based classification of single cardiomyocyte using deep learning. Front Physiol 12: 770051. https://doi.org/10.3389/fphys.2021.770051 doi: 10.3389/fphys.2021.770051 |
| Zhang Y, Qi Y, Li JJ, He WJ, Gao XH, Zhang Y, Sun X, Tong J, Zhang J, Deng XL, Du XJ, Xie W (2021) Stretch-induced sarcoplasmic reticulum calcium leak is causatively associated with atrial fibrillation in pressure-overloaded hearts. Cardiovasc Res 117(4): 1091−1102 doi: 10.1093/cvr/cvaa163 |